EC 3.2.1.49 - α-N-acetylgalactosaminidase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.2.1.49

Names

Accepted name:
α-N-acetylgalactosaminidase
Other names:
N-acetyl-α-D-galactosaminidase
N-acetyl-α-galactosaminidase
α-acetylgalactosaminidase
α-galactosidase B
α-NAGA
α-NAGAL
α-GalNAcase
Systematic name:
α-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase

Reaction

Comments:

The human lysosomal enzyme is involved in the degradation of blood type A epitope.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00443
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008456
CAS Registry Number: 9075-63-2
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Asfaw, B., Schindler, D., Ledvinova, J., Cerny, B., Smid, F., Conzelmann, E.
    Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.
    J. Lipid Res. 39: 1768-1780 (1998). [PMID: 9741689]
  2. Zhu, A., Monahan, C., Wang, Z. K., Goldstein, J.
    Expression, purification, and characterization of recombinant α-N-acetylgalactosaminidase produced in the yeast Pichia pastoris.
    Protein Expr. Purif. 8: 456-462 (1996). [PMID: 8954893]
  3. Clark, N. E., Garman, S. C.
    The 1.9 Å structure of human α-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases.
    J. Mol. Biol. 393: 435-447 (2009). [PMID: 19683538]
  4. Hoskins, L. C., Boulding, E. T., Larson, G.
    Purification and characterization of blood group A-degrading isoforms of α-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70
    J. Biol. Chem. 272: 7932-7939 (1997). [PMID: 9065462]
  5. Harun-Or-Rashid, M., Matsuzawa, T., Satoh, Y., Shiraishi, T., Ando, M., Sadik, G., Uda, Y.
    Purification and characterization of α-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis.
    Biosci. Biotechnol. Biochem. 74: 256-261 (2010). [PMID: 20139603]
  6. Weignerova, L., Filipi, T., Manglova, D., Kren, V.
    Induction, purification and characterization of α-N-acetylgalactosaminidase from Aspergillus niger.
    Appl. Microbiol. Biotechnol. 79: 769-774 (2008). [PMID: 18443780]
  7. Ashida, H., Tamaki, H., Fujimoto, T., Yamamoto, K., Kumagai, H.
    Molecular cloning of cDNA encoding α-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast.
    Arch. Biochem. Biophys. 384: 305-310 (2000). [PMID: 11368317]

[EC 3.2.1.49 created 1972, modified 2011]