EC 3.2.1.45 - Glucosylceramidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.45

Names

Accepted name:
glucosylceramidase
Other names:
β-D-glucocerebrosidase
β-glucosylceramidase
GlcCer-β-glucosidase
ceramide glucosidase
glucocerebrosidase
glucosphingosine glucosylhydrolase
glucosylcerebrosidase
glucosylsphingosine β-D-glucosidase
glucosylsphingosine β-glucosidase
psychosine hydrolase
β-glucocerebrosidase
acid β-glucosidase
Systematic name:
D-glucosyl-N-acylsphingosine glucohydrolase

Reaction

Comments:

Also acts on glucosylsphingosine (cf. EC 3.2.1.62 glycosylceramidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004348
CAS Registry Number: 37228-64-1
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Brady, R.O., Kanfer, J.N. and Shapiro, D.
    The metabolism of glucocerebrosides. I. Preparation and properties of a glucocerebroside-cleaving enzyme from spleen tissue.
    J. Biol. Chem. 240: 39-43 (1966).
  2. Vaccaro, A.M., Muscillo, M. and Suzuki, K.
    Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase.
    Eur. J. Biochem. 146: 315-321 (1985). [PMID: 3967661]

[EC 3.2.1.45 created 1972]