EC 184.108.40.206 - Chitinase
IntEnz Enzyme Nomenclature
- Random endo-hydrolysis of N-acetyl-β-D-glucosaminide (1→4)-β-linkages in chitin and chitodextrins
The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo-chitodextrinases can act. Activity is greatly stimulated in the presence of EC 220.127.116.11, lytic chitin monoxygenase, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. cf. EC 18.104.22.168, endo-chitodextrinase.
Links to other databases
Cleavage of O- and S-glycosidic bonds (survey).In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes, 2nd ed. vol. 4, Academic Press, New York, 1960, 301-312
Chitinase in some basidiomycetes.Biochem. J. 61: 579-586 (1955). [PMID: 13276340]
Chromatographic adsorption of the enzymes of emulsin which act on chitins.Enzymologia 7: 165-169 (1939).
Endochitinase is transported to the extracellular milieu by the eps-encoded general secretory pathway of Vibrio cholerae.J. Bacteriol. 180: 5591-5600 (1998). [PMID: 9791107]
The ChiA (YheB) protein of Escherichia coli K-12 is an endochitinase whose gene is negatively controlled by the nucleoid-structuring protein H-NS.Mol. Microbiol. 35: 1506-1517 (2000). [PMID: 10760150]
Chi18A, the endochitinase in the cellulosome of the thermophilic, cellulolytic bacterium Clostridium thermocellum.Appl. Environ. Microbiol. 68: 3176-3179 (2002). [PMID: 12039789]
Functional characterization of a class III acid endochitinase from the traps of the carnivorous pitcher plant genus, Nepenthes.J. Exp. Bot. 62: 4639-4647 (2011). [PMID: 21633084]
[EC 22.214.171.124 created 1961, modified 2017]