EC 3.2.1.114 - Mannosyl-oligosaccharide 1,3-1,6-α-mannosidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.114

Names

Accepted name:
mannosyl-oligosaccharide 1,3-1,6-α-mannosidase
Other names:
α-D-mannosidase II
α-mannosidase II
α1-3,6-mannosidase
GlcNAc transferase I-dependent α1,3[α1,6]mannosidase
Golgi α-mannosidase II
exo-1,3-1,6-α-mannosidase
mannosidase II
ManII
1,3(1,6)-α-D-mannosidase
1,3-(1,6-)mannosyl-oligosaccharide α-D-mannohydrolase
Systematic name:
(1→3)-(1→6)-mannosyl-oligosaccharide α-D-mannohydrolase

Reaction

Comments:

Involved in the synthesis of glycoproteins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004572
UniProtKB/Swiss-Prot:

References

  1. Harpaz, N. and Schachter, H.
    Control of glycoprotein synthesis. Processing of asparagine-linked oligosaccharides by one or more rat liver Golgi α-D-mannosidases dependent on the prior action of UDP-N-acetylglucosamine: α-D-mannoside β 2-N-acetylglucosaminyltransferase I.
    J. Biol. Chem. 255: 4894-4902 (1980). [PMID: 6445359]
  2. Tulsiani, D.R.P., Hubbard, S.C., Robbins, P.W. and Touster, O.
    α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases Ia and IB are the enzymes converting Man9 precursors to Man5 intermediates.
    J. Biol. Chem. 257: 3660-3668 (1982). [PMID: 7061502]
  3. Tulsiani, D.R.P., Opheim, D.J. and Touster, O.
    Purification and characterization of α-D-mannosidase from rat liver Golgi membranes.
    J. Biol. Chem. 252: 3227-3233 (1977). [PMID: 863880]
  4. Athanasopoulos, V.I., Niranjan, K. and Rastall, R.A.
    The production, purification and characterisation of two novel α-D-mannosidases from Aspergillus phoenicis.
    Carbohydr. Res. 340: 609-617 (2005). [PMID: 15721331]

[EC 3.2.1.114 created 1986]