EC 3.2.1.113 - Mannosyl-oligosaccharide 1,2-α-mannosidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.113

Names

Accepted name:
mannosyl-oligosaccharide 1,2-α-mannosidase
Other names:
1,2-α-mannosidase
Man9-mannosidase
exo-α-1,2-mannanase
glycoprotein processing mannosidase I
mannose-9 processing α-mannosidase
mannosidase 1A
mannosidase 1B
mannosidase I
ManI
1,2-α-mannosyl-oligosaccharide α-D-mannohydrolase
Systematic name:
2-α-mannosyl-oligosaccharide α-D-mannohydrolase

Reaction

Comments:

Involved in the synthesis of glycoproteins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004571
CAS Registry Number: 9068-25-1
UniProtKB/Swiss-Prot: (34) [show] [UniProt]

References

  1. Tabas, I. and Kornfeld, S.
    Purification and characterization of a rat liver Golgi α-mannosidase capable of processing asparagine-linked oligosaccharides.
    J. Biol. Chem. 254: 11655-11663 (1979). [PMID: 500665]
  2. Tulsiani, D.R.P., Hubbard, S.C., Robbins, P.W. and Touster, O.
    α-D-Mannosidases of rat liver Golgi membranes. Mannosidase II is the GlcNAcMAN5-cleaving enzyme in glycoprotein biosynthesis and mannosidases IA and IB are the enzymes converting Man9 precursors to Man5 intermediates.
    J. Biol. Chem. 257: 3660-3668 (1982). [PMID: 7061502]

[EC 3.2.1.113 created 1986]