EC 3.2.1.106 - Mannosyl-oligosaccharide glucosidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.106

Names

Accepted name:
mannosyl-oligosaccharide glucosidase
Other names:
Glc3Man9NAc2 oligosaccharide glucosidase
trimming glucosidase I
processing A-glucosidase I
Systematic name:
mannosyl-oligosaccharide glucohydrolase

Reaction

Comments:

Also acts, more slowly, on the corresponding glycolipids and glycopeptides. Involved in the formation of high-mannose and complex glycoproteins.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004573
UniProtKB/Swiss-Prot:

References

  1. Elting, J.J., Chen, W.W. and Lennarz, J.
    Characterization of a glucosidase involved in an initial step in the processing of oligosaccharide chains.
    J. Biol. Chem. 255: 2325-2331 (1980). [PMID: 7358674]
  2. Grinna, L.S. and Robbins, P.W.
    Glycoprotein biosynthesis. Rat liver microsomal glucosidases which process oligosaccharides.
    J. Biol. Chem. 254: 8814-8818 (1979). [PMID: 479161]
  3. Kilker, R.D., Saunier, B., Tkacz, J.S. and Herscovics, A.
    Partial purification from Saccharomyces cerevisiae of a soluble glucosidase which removes the terminal glucose from the oligosaccharide Glc3Man9GlcNAc2.
    J. Biol. Chem. 256: 5299-5603 (1981). [PMID: 7014569]
  4. Grinna, L.S. and Robbins, P.W.
    Substrate specificities of rat liver microsomal glucosidases which process glycoproteins.
    J. Biol. Chem. 255: 2255-2258 (1980). [PMID: 7358666]
  5. Mark, M.J. and Kornfeld, S.
    Partial purification and characterization of the glucosidases involved in the processing of asparagine-linked oligosaccharides.
    Arch. Biochem. Biophys. 199: 249-258 (1980). [PMID: 7356331]

[EC 3.2.1.106 created 1984]