EC 3.2.1.103 - Keratan-sulfate endo-1,4-β-galactosidase

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IntEnz Enzyme Nomenclature
EC 3.2.1.103

Names

Accepted name:
keratan-sulfate endo-1,4-β-galactosidase
Other names:
endo-β-galactosidase [ambiguous]
keratan sulfate endogalactosidase
keratanase
keratan-sulfate 1,4-β-D-galactanohydrolase
Systematic name:
keratan-sulfate 4-β-D-galactanohydrolase

Reaction

Comments:

Hydrolyses the 1,4-β-D-galactosyl linkages adjacent to 1,3-N-acetyl-α-D-glucosaminyl residues. Also acts on some non-sulfated oligosaccharides, but only acts on blood group substances when the 1,2-linked fucosyl residues have been removed (cf. EC 3.2.1.102 blood-group-substance endo-1,4-β-galactosidase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033930
UniProtKB/Swiss-Prot:

References

  1. Fukuda, M.N. and Matsumara, G.
    Endo-β-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein.
    J. Biol. Chem. 251: 6218-6225 (1976). [PMID: 135762]

[EC 3.2.1.103 created 1984]