EC - Cyclic-guanylate-specific phosphodiesterase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature


Accepted name:
cyclic-guanylate-specific phosphodiesterase
Other names:
cyclic bis(3→5')diguanylate phosphodiesterase
c-di-GMP-specific phosphodiesterase
c-di-GMP phosphodiesterase
phosphodiesterase A1
Systematic name:
cyclic bis(3→5')diguanylate 3-guanylylhydrolase




Requires Mg2+ or Mn2+ for activity and is inhibited by Ca2+ and Zn2+. Contains a heme unit. This enzyme linearizes cyclic di-3',5'-guanylate, the product of EC, diguanylate cyclase and an allosteric activator of EC, cellulose synthase (UDP-forming), rendering it inactive [1]. It is the balance between these two enzymes that determines the cellular level of c-di-GMP [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0071111
CAS Registry Number: 338732-46-0
UniProtKB/Swiss-Prot: (17) [show] [UniProt]


  1. Chang, A.L., Tuckerman, J.R., Gonzalez, G., Mayer, R., Weinhouse, H., Volman, G., Amikam, D., Benziman, M. and Gilles-Gonzalez, M.-A.
    Phosphodiesterase A1, a regulator of cellulose synthesis in Acetobacter xylinum, is a heme-based sensor.
    Biochemistry 40: 3420-3426 (2001). [PMID: 11297407]
  2. Christen, M., Christen, B., Folcher, M., Schauerte, A. and Jenal, U.
    Identification and characterization of a cyclic di-GMP-specific phosphodiesterase and its allosteric control by GTP.
    J. Biol. Chem. 280: 30829-30837 (2005). [PMID: 15994307]
  3. Schmidt, A.J., Ryjenkov, D.A. and Gomelsky, M.
    The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains.
    J. Bacteriol. 187: 4774-4781 (2005). [PMID: 15995192]
  4. Tamayo, R., Tischler, A.D. and Camilli, A.
    The EAL domain protein VieA is a cyclic diguanylate phosphodiesterase.
    J. Biol. Chem. 280: 33324-33330 (2005). [PMID: 16081414]

[EC created 2008]