EC 3.1.4.45 - N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase

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IntEnz Enzyme Nomenclature
EC 3.1.4.45

Names

Accepted name:
N-acetylglucosamine-1-phosphodiester α-N-acetylglucosaminidase
Other names:
2-acetamido-2-deoxy-α-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase
α-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase
α-N-acetylglucosaminyl phosphodiesterase
lysosomal α-N-acetylglucosaminidase
phosphodiester glycosidase
Systematic name:
glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase

Reaction

Comments:

Acts on a variety of compounds in which N-acetyl-D-glucosamine is α-linked to a phosphate group, including the biosynthetic intermediates of the high mannose oligosaccharide components of some lysosomal enzymes and the products of EC 2.7.8.17 UDP-N-acetylglucosamine—lysosomal-enzyme N-acetylglucosaminephosphotransferase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003944
UniProtKB/Swiss-Prot:

References

  1. Van den Tweel, W.J.J., Smits, J.P., Ogg, R.L.H.P. and De Bont, J.A.M.
    The involvement of an enantioselective transaminase in the metabolism of D-3- and D-4-hydroxyphenylglycine in Pseudomonas putida LW-4.
    Appl. Microbiol. Biotechnol. 29: 224-230 (1988).
  2. van der Drift, C., van Helvoort, P.E.M. and Vogels, G.D.
    S-Ureidoglycolate dehydrogenase: purification and properties.
    Arch. Biochem. Biophys. 145: 465-469 (1971). [PMID: 4399430]
  3. van der Drift, L., Vogels, G.D. and van der Drift, C.
    Allantoin racemase: a new enzyme from Pseudomonas species.
    Biochim. Biophys. Acta 391: 240-248 (1975). [PMID: 237557]
  4. Waheed, A., Hasilik, A. and von Figura, K.
    Processing of the phosphorylated recognition marker in lysosomal enzymes. Characterization and partial purification of a microsomal α-N-acetylglucosaminyl phosphodiesterase.
    J. Biol. Chem. 256: 5717-5721 (1981). [PMID: 6263889]

[EC 3.1.4.45 created 1984]