EC - Phospholipase C

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IntEnz Enzyme Nomenclature


Accepted name:
phospholipase C
Other names:
Clostridium oedematiens β- and γ-toxins
Clostridium welchii α-toxin
heat-labile hemolysin
lecithinase C
lipophosphodiesterase C
lipophosphodiesterase I
phosphatidase C
Systematic name:
phosphatidylcholine cholinephosphohydrolase




The bacterial enzyme, which is a zinc protein, also acts on sphingomyelin and phosphatidylinositol; that from seminal plasma does not act on phosphatidylinositol.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00357
Structural data: CSA , EC2PDB
Gene Ontology: GO:0034480 , GO:0004629
CAS Registry Number: 9001-86-9
UniProtKB/Swiss-Prot: (27) [show] [UniProt]


  1. Druzhinina, K.V. and Kritzman, M.G.
    [Lecithinase from animal tissues.] (in Russian)
    Biokhimiya 17: 77-81 (1952). [PMID: 13066482]
  2. Little, C. and Otnass, A.-B.
    The metal ion dependence of phospholipase C from Bacillus cereus.
    Biochim. Biophys. Acta 391: 326-333 (1975). [PMID: 807246]
  3. Sheiknejad, R.G. and Srivastava, P.N.
    Isolation and properties of a phosphatidylcholine-specific phospholipase C from bull seminal plasma.
    J. Biol. Chem. 261: 7544-7549 (1986). [PMID: 3086312]
  4. Takahashi, T., Sugahara, T. and Ohsaka, A.
    Purification of Clostridium perfringens phospholipase C (α-toxin) by affinity chromatography on agarose-linked egg-yolk lipoprotein.
    Biochim. Biophys. Acta 351: 155-171 (1974). [PMID: 4365891]

[EC created 1961]