EC 3.1.4.14 - [acyl-carrier-protein] phosphodiesterase

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IntEnz Enzyme Nomenclature
EC 3.1.4.14

Names

Accepted name:
[acyl-carrier-protein] phosphodiesterase
Other names:
ACP phosphodiesterase
ACP hydrolyase
AcpH
[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase
Systematic name:
holo-[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase

Reaction

Comments:

The enzyme cleaves acyl-[acyl-carrier-protein] species with acyl chains of 6-16 carbon atoms although it appears to demonstrate a preference for the unacylated acyl-carrier-protein (ACP) and short-chain ACPs over the medium- and long-chain species [3]. Deletion of the gene encoding this enzyme abolishes ACP prosthetic-group turnover in vivo [3]. Activation of apo-ACP to form the holoenzyme is carried out by EC 2.7.8.7, holo-[acyl-carrier-protein] synthase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008770
CAS Registry Number: 37288-21-4
UniProtKB/Swiss-Prot: (50) [show] [UniProt]

References

  1. Sobhy, C.
    Regulation of fatty acid synthetase activity. The 4'-phosphopantetheine hydrolase of rat liver.
    J. Biol. Chem. 254: 8561-8566 (1979). [PMID: 224058]
  2. Vagelos, P.R. and Larrabee, A.R.
    Acyl carrier protein. IX. Acyl carrier protein hydrolase.
    J. Biol. Chem. 242: 1776-1781 (1967). [PMID: 4290442]
  3. Thomas, J. and Cronan, J.E.
    The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization.
    J. Biol. Chem. 280: 34675-34683 (2005). [PMID: 16107329]

[EC 3.1.4.14 created 1972, modified 2006]