EC - Sphingomyelin phosphodiesterase

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IntEnz Enzyme Nomenclature


Accepted name:
sphingomyelin phosphodiesterase
Other names:
neutral sphingomyelinase
acid sphingomyelinase
Systematic name:
sphingomyelin cholinephosphohydrolase



Has very little activity on phosphatidylcholine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004767
CAS Registry Number: 9031-54-3
UniProtKB/Swiss-Prot: (31) [show] [UniProt]


  1. Barnholz, Y., Roitman, A. and Gatt, S.
    Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain.
    J. Biol. Chem. 241: 3731-3737 (1966). [PMID: 5916388]
  2. Chatterjee, S. and Ghosh, N.
    Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies.
    J. Biol. Chem. 264: 12554-12561 (1989). [PMID: 2545711]
  3. Heller, M. and Shapiro, B.
    Enzymic hydrolysis of sphingomyelin by rat liver.
    Biochem. J. 98: 763-769 (1966). [PMID: 5911524]
  4. Kanfer, J.N., Young, O.M., Shapiro, D. and Brady, R.O.
    The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue.
    J. Biol. Chem. 241: 1081-1084 (1966). [PMID: 5933867]

[EC created 1972]