EC 3.1.4.1 - Phosphodiesterase I

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IntEnz Enzyme Nomenclature
EC 3.1.4.1

Names

Accepted name:
phosphodiesterase I
Other names:
5'-exonuclease
5'-nucleotide phosphodiesterase
5'-phosphodiesterase
oligonucleate 5'-nucleotidohydrolase
5' nucleotide phosphodiesterase/alkaline phosphodiesterase I
5'-NPDase
5'-PDase
5'-PDE
5'NPDE
alkaline phosphodiesterase
nucleotide pyrophosphatase/phosphodiesterase I
orthophosphoric diester phosphohydrolase
PDE I
phosphodiesterase
exonuclease I
Systematic name:
oligonucleotide 5'-nucleotidohydrolase

Reaction

Comments:

Hydrolyses both ribonucleotides and deoxyribonucleotides. Has low activity towards polynucleotides. A 3'-phosphate terminus on the substrate inhibits hydrolysis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004528
CAS Registry Number: 9025-82-5
UniProtKB/Swiss-Prot: (23) [show] [UniProt]

References

  1. Khorana, G.H.
    Phosphodiesterases.
    In: Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.) The Enzymes., 2nd ed. vol. 5, Academic Press, New York, 1961, 79-94

[EC 3.1.4.1 created 1961]