EC 3.1.3.9 - Glucose-6-phosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.3.9

Names

Accepted name:
glucose-6-phosphatase
Other name:
glucose 6-phosphate phosphatase
Systematic name:
D-glucose-6-phosphate phosphohydrolase

Reactions

Comments:

Wide distribution in animal tissues. Also catalyses potent transphosphorylations from carbamoyl phosphate, hexose phosphates, diphosphate, phosphoenolpyruvate and nucleoside di- and triphosphates, to D-glucose, D-mannose, 3-methyl-D-glucose or 2-deoxy-D-glucose [cf. EC 2.7.1.62 (phosphoramidate-hexose phosphotransferase), EC 2.7.1.79 (diphosphate-glycerol phosphotransferase) and EC 3.9.1.1 (phosphoamidase)].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004346
CAS Registry Number: 9001-39-2
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Anchors, J.M. and Karnovsky, N.L.
    Purification of cerebral glucose-6-phosphatase. An enzyme involved in sleep.
    J. Biol. Chem. 250: 6408-6416 (1975). [PMID: 169241]
  2. Colilla, W., Jorgenson, R.A. and Nordlie, R.C.
    Mammalian carbamyl phosphate : glucose phosphotransferase and glucose-6-phosphate phosphohydrolase: extended tissue distribution.
    Biochim. Biophys. Acta 377: 117 (1975). [PMID: 164220]
  3. Nordlie, R.C.
    Glucose-6-phosphatase, hydrolytic and synthetic activities.
    In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 4, Academic Press, New York, 1971, 543-610
  4. Nordlie, R.C.
    Metabolic regulation by multifunctional glucose-6-phosphatase.
    Curr. Top. Cell. Regul. 8: 33 (1974). [PMID: 4370737]

[EC 3.1.3.9 created 1961]