EC - 2-phosphosulfolactate phosphatase

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IntEnz Enzyme Nomenclature


Accepted name:
2-phosphosulfolactate phosphatase
Other names:
(2R)-phosphosulfolactate phosphohydrolase
ComB phosphatase
Systematic name:
(R)-2-phospho-3-sulfolactate phosphohydrolase




Requires Mg2+. The enzyme from Methanococcus jannaschii acts on both stereoisoimers of the substrate and also hydrolyses a number of phosphate monoesters of (S)-2-hydroxycarboxylic acids, including 2-phosphomalate, 2-phospholactate and 2-phosphoglycolate. This enzyme can also hydrolyze phosphate monoesters of (R)-2-hydroxycarboxylic acids such as (S)-2-phospho-3-sulfolactate and (R)-2-phosphomalate, which, presumably, bind to the enzyme in opposite orientations.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050532
UniProtKB/Swiss-Prot: (60) [show] [UniProt]


  1. Graham, D.E., Graupner, M., Xu, H. and White, R.H.
    Identification of coenzyme M biosynthetic 2-phosphosulfolactate phosphatase.
    Eur. J. Biochem. 268: 5176-5188 (2001). [PMID: 11589710]

[EC created 2002]