EC 3.1.3.67 - Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.3.67

Names

Accepted name:
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Other names:
MMAC1
PTEN
phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase

Reaction

Cofactor

Comments:

Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3 .

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016314
UniProtKB/Swiss-Prot: (14) [show] [UniProt]

References

  1. Kabuyama, Y., Nakatsu, N., Homma, Y., Fukui, Y.
    Purification and characterization of phosphatidyl inositol-3,4,5-trisphosphate phosphatase in bovine thymus.
    Eur. J. Biochem. 238: 350-356 (1996). [PMID: 8681945]
  2. Maehama, T. and Dixon, J.E.
    The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.
    J. Biol. Chem. 273: 13375-13378 (1998). [PMID: 9593664]

[EC 3.1.3.67 created 1999, modified 2002]