EC 3.1.3.66 - Phosphatidylinositol-3,4-bisphosphate 4-phosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.3.66

Names

Accepted name:
phosphatidylinositol-3,4-bisphosphate 4-phosphatase
Other names:
D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
inositol polyphosphate 4-phosphatase
inositol polyphosphate 4-phosphatase type II
inositol-3,4-bisphosphate 4-phosphatase
phosphoinositide 4-phosphatase
Systematic name:
1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase

Reaction

Comments:

Mg2+-independent. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4)P3 to Ins(1,3)P2. It also converts Ins(3,4)P2 into Ins-3-P.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016316 , GO:0034597
CAS Registry Number: 122653-78-5
UniProtKB/Swiss-Prot:

References

  1. Howell, S., Barnaby, R.J., Rowe, T., Ragan, C.I. and Gee, N.S.
    Evidence for at least four different inositol bisphosphatases in bovine brain.
    Eur. J. Biochem. 183: 169-172 (1989). [PMID: 2546770]
  2. Norris, F.A., Auethavekiat, V. and Majerus, P.W.
    The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
    J. Biol. Chem. 270: 16128-16133 (1995). [PMID: 7608176]
  3. Norris, F.A., Atkins, R.C. and Majerus, P.W
    The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
    J. Biol. Chem. 272: 23859-23864 (1997). [PMID: 9295334]

[EC 3.1.3.66 created 1992, modified 2002]