EC 3.1.21.3 - Type I site-specific deoxyribonuclease

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IntEnz Enzyme Nomenclature
EC 3.1.21.3

Names

Accepted name:
type I site-specific deoxyribonuclease
Other names:
ATP-dependent DNase
adenosine triphosphate-dependent deoxyribonuclease
deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)
deoxyribonuclease (adenosine triphosphate-hydrolyzing)
restriction-modification system
type 1 site-specific deoxyribonuclease
type I restriction enzyme
Systematic name:
-

Reaction

Comments:

This is a large group of enzymes which, together with those now listed as EC 3.1.21.4 (type II site-specific deoxyribonuclease) and EC 3.1.21.5 (type III site-specific deoxyribonuclease), were previously listed separately in sub-subclasses EC 3.1.23 and EC 3.1.24. They have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine. They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence. They are multifunctional proteins that also catalyse the reactions of EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] and EC 2.1.1.73 [site-specific DNA-methyltransferase (cytosine-specific)], with similar site specificity. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available at http://rebase.neb.com/rebase/.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009035
CAS Registry Number: 37263-09-5
UniProtKB/Swiss-Prot: (17) [show] [UniProt]

References

  1. Roberts, R.J.
    Restriction enzymes and their isoschizomers.
    Nucleic Acids Res. 18: 2331-2365 (1990). [PMID: 2159140]
  2. Roberts, R.J. and Macelis, D.
    REBASE—restriction enzymes and methylases.
    Nucleic Acids Res. 29: 268-269 (2001). [PMID: 11125108]
  3. Roberts, R.J., Belfort, M., Bestor, T., Bhagwat, A.S., Bickle, T.A., Bitinaite, J., Blumenthal, R.M., Degtyarev, S.Kh., Dryden, D.T., Dybvig, K., Firman, K., Gromova, E.S., Gumport, R.I., Halford, S.E., Hattman, S., Heitman, J., Hornby, D.P., Janulaitis, A., Jeltsch, A., Josephsen, J., Kiss, A., Klaenhammer, T.R., Kobayashi, I., Kong, H., Krüger, D.H., Lacks, S., Marinus, M.G., Miyahara, M., Morgan, R.D., Murray, N.E., Nagaraja, V., Piekarowicz, A., Pingoud, A., Raleigh, E., Rao, D.N., Reich, N., Repin, V.E., Selker, E.U., Shaw, P.C., Stein, D.C., Stoddard, B.L., Szybalski, W., Trautner, T.A., Van Etten, J.L., Vitor, J.M., Wilson, G.G. and Xu, S.Y.
    A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
    Nucleic Acids Res. 31: 1805-1812 (2003). [PMID: 12654995]

[EC 3.1.21.3 created 1984 from EC 3.1.23 and EC 3.1.24]