EC 3.1.21.1 - Deoxyribonuclease I

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IntEnz Enzyme Nomenclature
EC 3.1.21.1

Names

Accepted name:
deoxyribonuclease I
Other names:
Escherichia coli endonuclease I
DNA depolymerase
DNA endonuclease
DNA nuclease
DNAase
DNase
DNase I
alkaline DNase
alkaline deoxyribonuclease
deoxyribonuclease (pancreatic)
deoxyribonuclease A
deoxyribonucleic phosphatase
dornava
dornavac
endodeoxyribonuclease I
pancreatic DNase
pancreatic deoxyribonuclease
pancreatic dornase
thymonuclease, dornase
Systematic name:

Reaction

Comments:

Preference for double-stranded DNA. Formerly EC 3.1.4.5.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00711
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004530
CAS Registry Number: 9003-98-9
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Privat de Garilhe, M. and Laskowski, M.
    Study of the enzymatic degradation of deoxyribonucleic acid by two different deoxyribonucleodepolymerases.
    J. Biol. Chem. 215: 269-276 (1955).
  2. Kunitz, M.
    Isolation of crystalline deoxyribonuclease from beef pancreas.
    Science 108: 19-20 (1948).
  3. Laskowski, M., Sr.
    Venom exonuclease.
    In: Boyer, P.D. (Ed.) The Enzymes, 3rd ed. vol. 4, Academic Press, New York, 1971, 313-328

[EC 3.1.21.1 created 1961 as EC 3.1.4.5, transferred 1978 to EC 3.1.21.1, modified 1981]