EC 3.1.11.2 - Exodeoxyribonuclease III

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IntEnz Enzyme Nomenclature
EC 3.1.11.2

Names

Accepted name:
exodeoxyribonuclease III
Other names:
E. coli exonuclease III
Escherichia coli exonuclease III
endoribonuclease III
exonuclease III
Systematic name:
-

Reaction

Comments:

Preference for double-stranded DNA. Has endonucleolytic activity near apurinic sites on DNA. Formerly EC 3.1.4.27.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00598
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008853
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Lindahl, T., Gally, J.A. and Edelman, G.M.
    Properties of deoxyribonuclease 3 from mammalian tissues.
    J. Biol. Chem. 244: 5014-5019 (1969). [PMID: 5824576]
  2. Richardson, C.C. and Kornberg, A.
    A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. I. Purification of the enzyme and characterization of the phosphatase activity.
    J. Biol. Chem. 239: 242-250 (1964). [PMID: 14114850]
  3. Richardson, C.C., Lehman, I.R. and Kornberg, A.
    A deoxyribonucleic acid phosphatase-exonuclease from Escherichia coli. II. Characterization of the exonuclease activity.
    J. Biol. Chem. 239: 251-258 (1964). [PMID: 14114851]

[EC 3.1.11.2 created 1972 as EC 3.1.4.27, transferred 1978 to EC 3.1.11.2]