EC 3.1.1.25 - 1,4-lactonase

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IntEnz Enzyme Nomenclature
EC 3.1.1.25

Names

Accepted name:
1,4-lactonase
Other name:
γ-lactonase
Systematic name:
1,4-lactone hydroxyacylhydrolase

Reactions

Cofactor

Comments:

The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050490
CAS Registry Number: 37278-38-9
UniProtKB/Swiss-Prot:

References

  1. Fishbein, W.N. and Bessman, S.P.
    Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of γ-lactones. I. Tissue localization, stoichiometry, specificity, distinction from esterase.
    J. Biol. Chem. 241: 4835-4841 (1966). [PMID: 4958984]
  2. Fishbein, W.N. and Bessman, S.P.
    Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of γ-lactones. II. Metal ion effects, kinetics, and equilibria.
    J. Biol. Chem. 241: 4842-4847 (1966). [PMID: 4958985]

[EC 3.1.1.25 created 1972, modified 1981]