EC 3.1.1.1 - Carboxylesterase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 3.1.1.1

Names

Accepted name:
carboxylesterase
Other names:
α-carboxylesterase
B-esterase
ali-esterase
butyrate esterase
butyryl esterase
carboxyesterase
carboxyl ester hydrolase
carboxylate esterase
carboxylic acid esterase
carboxylic esterase
cocaine esterase
esterase A
esterase B
esterase D
methylbutyrase
methylbutyrate esterase
monobutyrase
nonspecific carboxylesterase
procaine esterase
propionyl esterase
serine esterase
triacetin esterase
vitamin A esterase
Systematic name:
carboxylic-ester hydrolase

Reaction

Comments:

Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00112
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052689
CAS Registry Number: 9016-18-6
UniProtKB/Swiss-Prot: (98) [show] [UniProt]

References

  1. Augusteyn, R.C., de Jersey, J., Webb, E.C. and Zerner, B.
    On the homology of the active-site peptides of liver carboxylesterases.
    Biochim. Biophys. Acta 171: 128-137 (1969). [PMID: 4884138]
  2. Barker, D.L. and Jencks, W.P.
    Pig liver esterase. Physical properties.
    Biochemistry 8: 3879-3889 (1969). [PMID: 4981346]
  3. Bertram, J. and Krisch, K.
    Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney.
    Eur. J. Biochem. 11: 122-126 (1969). [PMID: 5353595]
  4. Burch, J.
    The purification and properties of horse liver esterase.
    Biochem. J. 58: 415-426 (1954).
  5. Horgan, D.J., Stoops, J.K., Webb, E.C. and Zerner, B.
    Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase.
    Biochemistry 8: 2000-2006 (1969). [PMID: 5785220]
  6. Malhotra, O.P. and Philip, G.
    Specificity of goat intestinal esterase.
    Biochem. Z. 346: 386-402 (1966).
  7. Mentlein, R., Schumann, M. and Heymann, E.
    Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes.
    Arch. Biochem. Biophys. 234: 612-621 (1984). [PMID: 6208846]
  8. Runnegar, M.T.C., Scott, K., Webb, E.C. and Zerner, B.
    Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase.
    Biochemistry 8: 2013-2018 (1969). [PMID: 5785222]

[EC 3.1.1.1 created 1961]