EC - Carboxylesterase

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IntEnz Enzyme Nomenclature


Accepted name:
Other names:
butyrate esterase
butyryl esterase
carboxyl ester hydrolase
carboxylate esterase
carboxylic acid esterase
carboxylic esterase
cocaine esterase
esterase A
esterase B
esterase D
methylbutyrate esterase
nonspecific carboxylesterase
procaine esterase
propionyl esterase
serine esterase
triacetin esterase
vitamin A esterase
Systematic name:
carboxylic-ester hydrolase



Wide specificity. The enzymes from microsomes also catalyse the reactions of EC (arylesterase), EC (lysophospholipase), EC (acetylesterase), EC (acylglycerol lipase), EC (acylcarnitine hydrolase), EC (palmitoyl-CoA hydrolase), EC (amidase) and EC (aryl-acylamidase). Also hydrolyses vitamin A esters.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UM-BBD , UniPathway
Protein domains and families: PROSITE:PDOC00112
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052689
CAS Registry Number: 9016-18-6
UniProtKB/Swiss-Prot: (98) [show] [UniProt]


  1. Augusteyn, R.C., de Jersey, J., Webb, E.C. and Zerner, B.
    On the homology of the active-site peptides of liver carboxylesterases.
    Biochim. Biophys. Acta 171: 128-137 (1969). [PMID: 4884138]
  2. Barker, D.L. and Jencks, W.P.
    Pig liver esterase. Physical properties.
    Biochemistry 8: 3879-3889 (1969). [PMID: 4981346]
  3. Bertram, J. and Krisch, K.
    Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney.
    Eur. J. Biochem. 11: 122-126 (1969). [PMID: 5353595]
  4. Burch, J.
    The purification and properties of horse liver esterase.
    Biochem. J. 58: 415-426 (1954).
  5. Horgan, D.J., Stoops, J.K., Webb, E.C. and Zerner, B.
    Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase.
    Biochemistry 8: 2000-2006 (1969). [PMID: 5785220]
  6. Malhotra, O.P. and Philip, G.
    Specificity of goat intestinal esterase.
    Biochem. Z. 346: 386-402 (1966).
  7. Mentlein, R., Schumann, M. and Heymann, E.
    Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes.
    Arch. Biochem. Biophys. 234: 612-621 (1984). [PMID: 6208846]
  8. Runnegar, M.T.C., Scott, K., Webb, E.C. and Zerner, B.
    Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase.
    Biochemistry 8: 2013-2018 (1969). [PMID: 5785222]

[EC created 1961]