EC 2.9.1.1 - L-seryl-tRNASec selenium transferase

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IntEnz Enzyme Nomenclature
EC 2.9.1.1

Names

Accepted name:
L-seryl-tRNASec selenium transferase
Other names:
L-selenocysteinyl-tRNASec synthase
L-selenocysteinyl-tRNASel synthase
cysteinyl-tRNASec-selenium transferase
selenocysteine synthase
cysteinyl-tRNASel-selenium transferase
Systematic name:
selenophosphate:L-seryl-tRNASec selenium transferase

Reaction

Cofactor

Comments:

A pyridoxal 5'-phosphate enzyme identified in Escherichia coli. Recognises specifically tRNASec-species. Binding of tRNASec also occurs in the absence of the seryl group. 2-Aminoacryloyl-tRNA, bound to the enzyme as an imine with the pyridoxal phosphate, is an intermediate in the reaction. Since the selenium atom replaces oxygen in serine, the product may also be referred to as L-selenoseryl-tRNASec. The symbol Sel has also been used for selenocysteine but Sec is preferred.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004125
CAS Registry Numbers: 183869-06-9 211752-49-7
UniProtKB/Swiss-Prot: (127) [show] [UniProt]

References

  1. Forchhammer, K. and Böck, A.
    Selenocysteine from Escherichia coli. Analysis of the reaction sequence.
    J. Biol. Chem. 266: 6324-6328 (1991). [PMID: 2007585]

[EC 2.9.1.1 created 1999]