EC 2.8.3.5 - 3-oxoacid CoA-transferase

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IntEnz Enzyme Nomenclature
EC 2.8.3.5

Names

Accepted name:
3-oxoacid CoA-transferase
Other names:
3-ketoacid CoA-transferase
3-ketoacid coenzyme A transferase
3-oxo-CoA transferase
3-oxoacid CoA dehydrogenase
3-oxoacid coenzyme A-transferase
acetoacetate succinyl-CoA transferase
acetoacetyl coenzyme A-succinic thiophorase
succinyl coenzyme A-acetoacetyl coenzyme A-transferase
succinyl-CoA transferase
succinyl-CoA:3-ketoacid-CoA transferase
Systematic name:
succinyl-CoA:3-oxo-acid CoA-transferase

Reaction

Comments:

Acetoacetate and, more slowly, 3-oxopropanoate, 3-oxopentanoate, 3-oxo-4-methylpentanoate or 3-oxohexanoate can act as acceptors; malonyl-CoA can act instead of succinyl-CoA.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00980
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008260
CAS Registry Number: 9027-43-4
UniProtKB/Swiss-Prot: (27) [show] [UniProt]

References

  1. Hersh, L.B. and Jencks, W.P.
    Coenzyme A transferase. Kinetics and exchange reactions.
    J. Biol. Chem. 242: 3468-3480 (1967).
  2. Lynen, F. and Ochoa, S.
    Enzymes of fatty acid metabolism.
    Biochim. Biophys. Acta 12: 299-314 (1953). [PMID: 13115439]
  3. Menon, G.K.K. and Stern, J.R.
    Enzymic synthesis and metabolism of malonyl coenzyme A and glutaryl coenzyme A.
    J. Biol. Chem. 235: 3393-3398 (1960). [PMID: 13769479]
  4. Stern, J.R., Coon, M.J., del Campillo, A. and Schneider, M.C.
    Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase.
    J. Biol. Chem. 221: 15-31 (1956). [PMID: 13345795]

[EC 2.8.3.5 created 1961, modified 1980]