EC 2.7.7.61 - Citrate lyase holo-[acyl-carrier protein] synthase

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IntEnz Enzyme Nomenclature
EC 2.7.7.61

Names

Accepted name:
citrate lyase holo-[acyl-carrier protein] synthase
Other names:
2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase
CitX
holo-citrate lyase synthase [incorrect]
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase adenylyltransferase
holo-ACP synthase [ambiguous]
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA transferase
2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase adenylyltransferase
2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate-lyase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase
Systematic name:
2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-[citrate (pro-3S)-lyase] 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase

Reaction

Comments:

The γ-subunit of EC 4.1.3.6, citrate (pro-3S) lyase, serves as an acyl-carrier protein (ACP) and contains the prosthetic group 2'-(5-triphosphoribosyl)-3'-dephospho-CoA [1,3]. Synthesis and attachment of the prosthetic group requires the concerted action of this enzyme and EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase [1]. In the enzyme from Escherichia coli, the prosthetic group is attached to serine-14 of the ACP via a phosphodiester bond.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050519
CAS Registry Number: 312492-44-7
UniProtKB/Swiss-Prot: (36) [show] [UniProt]

References

  1. Schneider, K., Dimroth, P. and Bott, M.
    Biosynthesis of the prosthetic group of citrate lyase.
    Biochemistry 39: 9438-9450 (2000). [PMID: 10924139]
  2. Schneider, K., Dimroth, P. and Bott, M.
    Identification of triphosphoribosyl-dephospho-CoA as precursor of the citrate lyase prosthetic group.
    FEBS Lett. 483: 165-168 (2000). [PMID: 11042274]
  3. Schneider, K., Kästner, C.N., Meyer, M., Wessel, M., Dimroth, P. and Bott, M.
    Identification of a gene cluster in Klebsiella pneumoniae which includes citX, a gene required for biosynthesis of the citrate lyase prosthetic group.
    J. Bacteriol. 184: 2439-2446 (2002). [PMID: 11948157]

[EC 2.7.7.61 created 2002, modified 2008]