EC - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

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IntEnz Enzyme Nomenclature


Accepted name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Other names:
MEP cytidylyltransferase
4-diphosphocytidyl-2-C-methyl-D-erythritol synthase
Systematic name:
CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase




The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050518
UniProtKB/Swiss-Prot: (455) [show] [UniProt]


  1. Kuzuyama, T., Takagi, M., Kaneda, K., Dairi, T. and Seto, H.
    Formation of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol from 2-C-methyl-D-erythritol 4-phosphate by 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, a new enzyme in the nonmevalonate pathway.
    Tetrahedron Lett. 41: 703-706 (2000).
  2. Rohdich, F., Wungsintaweekul, J., Fellermeier, M., Sagner, S., Herz, S., Kis, K., Eisenreich, W., Bacher, A. and Zenk, M.H.
    Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.
    Proc. Natl. Acad. Sci. USA 96: 11758-11763 (1999). [PMID: 10518523]

[EC created 2001]