EC 2.7.7.50 - MRNA guanylyltransferase

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IntEnz Enzyme Nomenclature
EC 2.7.7.50

Names

Accepted name:
mRNA guanylyltransferase
Other names:
protein λ2
mRNA capping enzyme
messenger RNA guanylyltransferase
GTP—RNA guanylyltransferase
Systematic name:
GTP:mRNA guanylyltransferase

Reaction

Comments:

The enzyme can also modify synthetic poly(A) and poly(G) to form the structures m7G(5')pppAn and m7G(5')pppGn.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004484
CAS Registry Number: 56941-23-2
UniProtKB/Swiss-Prot: (77) [show] [UniProt]

References

  1. Ensinger, M.J., Martin, S.A., Paoletti, E. and Moss, B.
    Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
    Proc. Natl. Acad. Sci. USA 72: 2525-2529 (1975). [PMID: 1058472]
  2. Groner, Y., Gilbao, E. and Aviv, H.
    Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
    Biochemistry 17: 977-982 (1978). [PMID: 629955]
  3. Itoh, N., Yamada, H., Kaziro, Y. and Mizumoto, K.
    Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization.
    J. Biol. Chem. 262: 1989-1995 (1987). [PMID: 3029058]
  4. Martin, S.A. and Moss, B.
    Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions.
    J. Biol. Chem. 250: 9330-9335 (1975). [PMID: 1194287]
  5. Martin, S.A., Paoletti, E. and Moss, B.
    Purification of mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions.
    J. Biol. Chem. 250: 9322-9329 (1975). [PMID: 1194286]

[EC 2.7.7.50 created 1981]