EC 2.7.6.1 - Ribose-phosphate diphosphokinase

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IntEnz Enzyme Nomenclature
EC 2.7.6.1

Names

Accepted name:
ribose-phosphate diphosphokinase
Other names:
5-phosphoribose pyrophosphorylase
5-phosphoribosyl-1-pyrophosphate synthetase
5-phosphoribosyl-alpha-1-pyrophosphate synthetase
PP-ribose P synthetase
PPRibP synthetase
PRPP synthetase
phosphoribosyl-diphosphate synthetase
phosphoribosylpyrophosphate synthase
phosphoribosylpyrophosphate synthetase
pyrophosphoribosylphosphate synthetase
ribophosphate pyrophosphokinase
ribose-5-phosphate pyrophosphokinase
ribose-phosphate pyrophosphokinase
Systematic name:
ATP:D-ribose-5-phosphate diphosphotransferase

Reaction

Comments:

dATP can also act as donor.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ERGO , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00105
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004749
CAS Registry Number: 9015-83-2
UniProtKB/Swiss-Prot: (203) [show] [UniProt]

References

  1. Hughes, D.E. and Williamson, D.H.
    Some properties of glutaminase of Clostridium welchii.
    Biochem. J. 51: 45-55 (1952).
  2. Hurlbert, R.B. and Reichard, P.
    The conversion of orotic acid to uridine nucleotides in vitro.
    Acta Chem. Scand. 9: 251-262 (1955).
  3. Remy, C.N., Remy, W.T. and Buchanan, J.M.
    Biosynthesis of the purines. VIII. Enzymatic synthesis and utilization of α-5-phosphoribosylpyrophosphate.
    J. Biol. Chem. 217: 885-895 (1955).
  4. Switzer, R.L.
    Regulation and mechanism of phosphoribosylpyrophosphate synthetase. I. Purification and properties of the enzyme from Salmonella typhimurium.
    J. Biol. Chem. 244: 2854-2863 (1969). [PMID: 4306285]

[EC 2.7.6.1 created 1961]