EC - UMP kinase

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IntEnz Enzyme Nomenclature


Accepted name:
UMP kinase
Other names:
uridylate kinase
uridine monophosphate kinase
Systematic name:
ATP:UMP phosphotransferase



This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033862
UniProtKB/Swiss-Prot: (553) [show] [UniProt]


  1. Serina, L., Blondin, C., Krin, E., Sismeiro, O., Danchin, A., Sakamoto, H., Gilles, A.M. and Bârzu, O.
    Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP.
    Biochemistry 34: 5066-5074 (1995). [PMID: 7711027]
  2. Marco-Marín, C., Gil-Ortiz, F. and Rubio, V.
    The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis.
    J. Mol. Biol. 352: 438-454 (2005). [PMID: 16095620]

[EC created 2006]