EC 2.7.4.22 - UMP kinase

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IntEnz Enzyme Nomenclature
EC 2.7.4.22

Names

Accepted name:
UMP kinase
Other names:
uridylate kinase
UMPK
uridine monophosphate kinase
PyrH
UMP-kinase
SmbA
Systematic name:
ATP:UMP phosphotransferase

Reaction

Comments:

This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose [2]. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP [1].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033862
UniProtKB/Swiss-Prot: (553) [show] [UniProt]

References

  1. Serina, L., Blondin, C., Krin, E., Sismeiro, O., Danchin, A., Sakamoto, H., Gilles, A.M. and Bârzu, O.
    Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP.
    Biochemistry 34: 5066-5074 (1995). [PMID: 7711027]
  2. Marco-Marín, C., Gil-Ortiz, F. and Rubio, V.
    The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis.
    J. Mol. Biol. 352: 438-454 (2005). [PMID: 16095620]

[EC 2.7.4.22 created 2006]