EC 2.7.4.14 - UMP/CMP kinase

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IntEnz Enzyme Nomenclature
EC 2.7.4.14

Names

Accepted name:
UMP/CMP kinase
Other names:
ATP:UMP-CMP phosphotransferase
CMP kinase
CTP:CMP phosphotransferase
UMP-CMP kinase
dCMP kinase
deoxycytidine monophosphokinase
deoxycytidylate kinase
pyrimidine nucleoside monophosphate kinase
deoxycytidine kinase
cytidine monophosphate kinase
cytidylate kinase
uridine monophosphate-cytidine monophosphate phosphotransferase
Systematic name:
ATP:CMP(UMP) phosphotransferase

Reactions

Comments:

This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Protein domains and families: PROSITE:PDOC00104
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004127
CAS Registry Number: 37278-21-0
UniProtKB/Swiss-Prot: (52) [show] [UniProt]

References

  1. Hurwitz, J.
    The enzymatic incorporation of ribonucleotides into polydeoxynucleotide material.
    J. Biol. Chem. 234: 2351-2358 (1959).
  2. Ruffner, B.W., Jr. and Anderson, E.P.
    Adenosine triphosphate: uridine monophosphate-cytidine monophosphate phosphotransferase from Tetrahymena pyriformis.
    J. Biol. Chem. 244: 5994-6002 (1969). [PMID: 5350952]
  3. Scheffzek, K., Kliche, W., Wiesmuller, L., Reinstein, J.
    Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 Å: implications for water-mediated specificity.
    Biochemistry 35: 9716-9727 (1996). [PMID: 8703943]
  4. Zhou, L., Lacroute, F., Thornburg, R.
    Cloning, expression in Escherichia coli, and characterization of Arabidopsis thaliana UMP/CMP kinase.
    Plant Physiol. 117: 245-254 (1998). [PMID: 9576794]
  5. Van Rompay, A. R., Johansson, M., Karlsson, A.
    Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: molecular characterization of the human enzyme.
    Mol. Pharmacol. 56: 562-569 (1999). [PMID: 10462544]

[EC 2.7.4.14 created 1961 as EC 2.7.4.5, transferred 1972 to EC 2.7.4.14, modified 1980, modified 2010, modified 2011]