EC - Phosphoenolpyruvate—protein phosphotransferase

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IntEnz Enzyme Nomenclature


Accepted name:
phosphoenolpyruvate—protein phosphotransferase
Other names:
phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase
phosphoenolpyruvate sugar phosphotransferase enzyme I
phosphopyruvate—protein factor phosphotransferase
phosphopyruvate—protein phosphotransferase
sugar—PEP phosphotransferase enzyme I
phosphoenolpyruvate—protein phosphatase
enzyme I of the phosphotransferase system
Systematic name:
phosphoenolpyruvate:protein-L-histidine Nπ-phosphotransferase



Enzyme I of the phosphotransferase system (cf. EC protein-Nπ-phosphohistidine—sugar phosphotransferase). Acts only on histidine residues in specific phosphocarrier proteins of low molecular mass (9.5 kDa) involved in bacterial sugar transport. A similar reaction, where the protein is the enzyme EC pyruvate, water dikinase, is part of the mechanism of that enzyme.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00527
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008965
CAS Registry Number: 37278-17-4
UniProtKB/Swiss-Prot: (51) [show] [UniProt]


  1. Postma, P.W. and Roseman, S.
    The bacterial phosphoenolpyruvate: sugar phosphotransferase system.
    Biochim. Biophys. Acta 457: 213-257 (1976). [PMID: 187249]

[EC created 1972]