EC 2.7.11.16 - G-protein-coupled receptor kinase

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IntEnz Enzyme Nomenclature
EC 2.7.11.16

Names

Accepted name:
G-protein-coupled receptor kinase
Other names:
G protein-coupled receptor kinase
GPCR kinase
GPCRK
GRK4
GRK5
GRK6
STK16
Systematic name:
ATP:[G-protein-coupled receptor] phosphotransferase

Reaction

Comments:

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). All members of this enzyme subfamily possess a highly conserved binding site for 1-phosphatidylinositol 4,5-bisphosphate. (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.15, β-adrenergic-receptor kinase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00100
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004703
UniProtKB/Swiss-Prot: (15) [show] [UniProt]

References

  1. Kunapuli, P., Onorato, J.J., Hosey, M.M. and Benovic, J.L.
    Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
    J. Biol. Chem. 269: 1099-1105 (1994). [PMID: 8288567]
  2. Premont, R.T., Koch, W.J., Inglese, J. and Lefkowitz, R.J.
    Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
    J. Biol. Chem. 269: 6832-6841 (1994). [PMID: 8120045]
  3. Willets, J.M., Challiss, R.A.J. and Nahorski, S.R.
    Non-visual GRKs: are we seeing the whole picture?
    Trends Pharmacol. Sci. 24: 626-633 (2003). [PMID: 14654303]

[EC 2.7.11.16 created 2005]