EC 2.7.11.15 - β-adrenergic-receptor kinase

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IntEnz Enzyme Nomenclature
EC 2.7.11.15

Names

Accepted name:
β-adrenergic-receptor kinase
Other names:
β-adrenergic-receptor kinase
ATP:β-adrenergic-receptor phosphotransferase
β-adrenergic receptor-specific kinase
β-AR kinase
β-ARK
β-ARK 1
β-ARK 2
β-receptor kinase
GRK2
GRK3
β-adrenergic-receptor kinase (phosphorylating)
β2ARK
βARK1
β-adrenoceptor kinase
β-adrenoceptor kinase 1
β-adrenoceptor kinase 2
ADRBK1
BARK1
adrenergic receptor kinase
STK15
[β-adrenergic-receptor] kinase
Systematic name:
ATP:[β-adrenergic-receptor] phosphotransferase

Reaction

Comments:

Requires G-protein for activation and therefore belongs to the family of G-protein-dependent receptor kinases (GRKs). Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. Does not act on casein or histones. The enzyme is inhibited by Zn2+ and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14, rhodopsin kinase and EC 2.7.11.16, G-protein-coupled receptor kinase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00100
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047696
CAS Registry Number: 102925-39-3
UniProtKB/Swiss-Prot: (10) [show] [UniProt]

References

  1. Benovic, J.L., Mayor, F., Jr., Staniszewski, C., Lefkowitz, R.J. and Caron, M.G.
    Purification and characterization of the β-adrenergic receptor kinase.
    J. Biol. Chem. 262: 9026-9032 (1987). [PMID: 3036840]
  2. Kim, C.M., Dion, S.B., Onorato, J.J. and Benovic, J.L.
    Expression and characterization of two β-adrenergic receptor kinase isoforms using the baculovirus expression system.
    Receptor 3: 39-55 (1993). [PMID: 8394172]
  3. Laugwitz, K.-L., Kronsbein, K., Schmitt, M., Hoffmann, K., Seyfarth, M., Schömig, A. and Ungerer, M.
    Characterization and inhibition of β-adrenergic receptor kinase in intact myocytes.
    Cardiovasc. Res. 35: 324-333 (1997). [PMID: 9349395]
  4. Ferguson, S.S., Ménard, L., Barak, L.S., Koch, W.J., Colapietro, A.-M. and Caron, M.G.
    Role of phosphorylation in agonist-promoted β 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by β ARK1.
    J. Biol. Chem. 270: 24782-24789 (1995). [PMID: 7559596]
  5. Willets, J.M., Challiss, R.A.J. and Nahorski, S.R.
    Non-visual GRKs: are we seeing the whole picture?
    Trends Pharmacol. Sci. 24: 626-633 (2003). [PMID: 14654303]

[EC 2.7.11.15 created 1989 as EC 2.7.1.126, transferred 2005 to EC 2.7.11.15]