EC 2.7.1.78 - Polynucleotide 5'-hydroxyl-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.78

Names

Accepted name:
polynucleotide 5'-hydroxyl-kinase
Other names:
5'-hydroxyl RNA kinase
5'-hydroxyl polynucleotide kinase
5'-hydroxyl polyribonucleotide kinase
ATP:5'-dephosphopolynucleotide 5'-phosphatase
DNA 5'-hydroxyl kinase
DNA kinase
PNK
polynucleotide 5'-hydroxyl kinase (phosphorylating)
polynucleotide kinase
polynucleotide 5'-hydroxy-kinase
Systematic name:
ATP:5'-dephosphopolynucleotide 5'-phosphotransferase

Reactions

Comments:

Also acts on 5'-dephospho-RNA 3'-mononucleotides.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046404
CAS Registry Number: 37211-65-7
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Novogrodsky, A. and Hurwitz, J.
    The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. I. Phosphorylation at 5'-hydroxyl termini.
    J. Biol. Chem. 241: 2923-2932 (1966). [PMID: 4287929]
  2. Novogrodsky, A., Tal, M., Traub, A. and Hurwitz, J.
    The enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase.
    J. Biol. Chem. 241: 2933-2943 (1966). [PMID: 4287930]

[EC 2.7.1.78 created 1972]