EC 2.7.1.74 - Deoxycytidine kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.74

Names

Accepted name:
deoxycytidine kinase
Other names:
2'-deoxycytidine kinase
Ara-C kinase
arabinofuranosylcytosine kinase
deoxycytidine kinase (phosphorylating)
deoxycytidine-cytidine kinase
Systematic name:
NTP:deoxycytidine 5'-phosphotransferase

Reactions

Comments:

Cytosine arabinoside can act as acceptor; all natural nucleoside triphosphates (except dCTP) can act as donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004137
CAS Registry Number: 9039-45-6
UniProtKB/Swiss-Prot:

References

  1. Durham, J.P. and Ives, D.H.
    Deoxycytidine kinase. II. Purification and general properties of the calf thymus enzyme.
    J. Biol. Chem. 245: 2276-2284 (1970). [PMID: 5442271]
  2. Ives, D.H. and Durham, J.P.
    Deoxycytidine kinase. 3. Kinetics and allosteric regulation of the calf thymus enzyme.
    J. Biol. Chem. 245: 2285-2294 (1970). [PMID: 5462538]
  3. Kessel, D.
    Properties of deoxycytidine kinase partially purified from L1210 cells.
    J. Biol. Chem. 243: 4739-4744 (1968).
  4. Momparler, R.L. and Fischer, G.A.
    Mammalian deoxynucleoside kinase. I. Deoxycytidine kinase: purification, properties, and kinetic studies with cytosine arabinoside.
    J. Biol. Chem. 243: 4298-4304 (1968). [PMID: 5684726]

[EC 2.7.1.74 created 1972]