EC 2.7.1.52 - Fucokinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.52

Names

Accepted name:
fucokinase
Other names:
L-fucokinase
L-fucose kinase
ATP:6-deoxy-L-galactose 1-phosphotransferase
fucokinase (phosphorylating)
fucose kinase
Systematic name:
ATP:β-L-fucose 1-phosphotransferase

Reaction

Cofactor

Comments:

Requires a divalent cation for activity, with Mg2+ and Fe2+ giving rise to the highest enzyme activity. Forms part of a salvage pathway for reutilization of L-fucose. Can also phosphorylate D-arabinose, but more slowly.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0050201
CAS Registry Number: 37278-00-5
UniProtKB/Swiss-Prot:

References

  1. Ishihara, H., Massaro, D.J. and Heath, E.C.
    The metabolism of L-fucose. 3. The enzymatic synthesis of β-L-fucose 1-phosphate
    . J. Biol. Chem. 243: 1103-1109 (1968). [PMID: 5646161]
  2. Butler, W. and Serif, G.S.
    Fucokinase, its anomeric specificity and mechanism of phosphate group transfer.
    Biochim. Biophys. Acta 829: 238-243 (1985). [PMID: 2986701]
  3. Park, S.H., Pastuszak, I., Drake, R. and Elbein, A.D.
    Purification to apparent homogeneity and properties of pig kidney L-fucose kinase.
    J. Biol. Chem. 273: 5685-5691 (1998). [PMID: 9488699]

[EC 2.7.1.52 created 1972, modified 2004]