EC 2.7.1.48 - Uridine kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.48

Names

Accepted name:
uridine kinase
Other names:
pyrimidine ribonucleoside kinase
uridine kinase (phosphorylating)
uridine phosphokinase
uridine-cytidine kinase
Systematic name:
ATP:uridine 5'-phosphotransferase

Reactions

Comments:

Cytidine can act as acceptor; GTP and ITP can act as donors.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004849
CAS Registry Number: 9026-39-5
UniProtKB/Swiss-Prot: (234) [show] [UniProt]

References

  1. Orengo, A.
    Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor.
    J. Biol. Chem. 244: 2204-2209 (1969). [PMID: 5782006]
  2. Sköld, O.
    Uridine kinase from Erlich ascites tumor: purification and properties.
    J. Biol. Chem. 235: 3273-3279 (1960).
  3. Suzuki, N. N., Koizumi, K., Fukushima, M., Matsuda, A., Inagaki, F.
    Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase.
    Structure 12: 751-764 (2004). [PMID: 15130468]
  4. Pasti, C., Gallois-Montbrun, S., Munier-Lehmann, H., Veron, M., Gilles, A. M., Deville-Bonne, D.
    Reaction of human UMP-CMP kinase with natural and analog substrates.
    Eur. J. Biochem. 270: 1784-1790 (2003). [PMID: 12694191]

[EC 2.7.1.48 created 1965]