EC 2.7.1.159 - Inositol-1,3,4-trisphosphate 5/6-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.159

Names

Accepted name:
inositol-1,3,4-trisphosphate 5/6-kinase
Other names:
Ins(1,3,4)P3 5/6-kinase
inositol trisphosphate 5/6-kinase
IP56K
Systematic name:
ATP:1D-myo-inositol 1,3,4-trisphosphate 5-phosphotransferase

Reactions

Comments:

In humans, this enzyme, along with EC 2.7.1.127 (inositol-trisphosphate 3-kinase), EC 2.7.1.140 (inositol-tetrakisphosphate 5-kinase) and EC 2.7.1.158 (inositol pentakisphosphate 2-kinase) is involved in the production of inositol hexakisphosphate (InsP6). InsP6 is involved in many cellular processes, including mRNA export from the nucleus [2]. Yeast do not have this enzyme, so produce InsP6 from Ins(1,4,5)P3 by the actions of EC 2.7.1.151 (inositol-polyphosphate multikinase) and EC 2.7.1.158 (inositol-pentakisphosphate 2-kinase) [2].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC50975
Structural data: CSA , EC2PDB
Gene Ontology: GO:0052726 , GO:0052725
CAS Registry Number: 288307-53-9
UniProtKB/Swiss-Prot: (24) [show] [UniProt]

References

  1. Wilson, M.P. and Majerus, P.W.
    Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.
    J. Biol. Chem. 271: 11904-11910 (1996). [PMID: 8662638]
  2. Verbsky, J.W., Chang, S.C., Wilson, M.P., Mochizuki, Y. and Majerus, P.W.
    The pathway for the production of inositol hexakisphosphate in human cells.
    J. Biol. Chem. 280: 1911-1920 (2005). [PMID: 15531582]
  3. Miller, G.J., Wilson, M.P., Majerus, P.W. and Hurley, J.H.
    Specificity determinants in inositol polyphosphate synthesis: crystal structure of inositol 1,3,4-trisphosphate 5/6-kinase.
    Mol. Cell 18: 201-212 (2005). [PMID: 15837423]

[EC 2.7.1.159 created 2006]