EC 2.7.1.157 - N-acetylgalactosamine kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.157

Names

Accepted name:
N-acetylgalactosamine kinase
Other names:
GALK2
GK2
GalNAc kinase
N-acetylgalactosamine (GalNAc)-1-phosphate kinase
ATP:N-acetyl-D-galactosamine 1-phosphotransferase
Systematic name:
ATP:N-acetyl-α-D-galactosamine 1-phosphotransferase

Reaction

Cofactor

Comments:

The enzyme is highly specific for GalNAc as substrate, but has slight activity with D-galactose [2]. Requires Mg2+, Mn2+ or Co2+ for activity, with Mg2+ resulting in by far the greatest stimulation of enzyme activity.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00099 , PROSITE:PDOC00545
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033858
UniProtKB/Swiss-Prot:

References

  1. Pastuszak, I., Drake, R. and Elbein, A.D.
    Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation.
    J. Biol. Chem. 271: 20776-20782 (1996). [PMID: 8702831]
  2. Pastuszak, I., O'Donnell, J., Elbein and A.D.
    Identification of the GalNAc kinase amino acid sequence.
    J. Biol. Chem. 271: 23653-23656 (1996). [PMID: 8798585]
  3. Thoden, J.B. and Holden, H.M.
    The molecular architecture of human N-acetylgalactosamine kinase.
    J. Biol. Chem. 280: 32784-32791 (2005). [PMID: 16006554]

[EC 2.7.1.157 created 2005]