EC 2.7.1.154 - Phosphatidylinositol-4-phosphate 3-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.154

Names

Accepted name:
phosphatidylinositol-4-phosphate 3-kinase
Other names:
phosphoinositide 3-kinase
type II phosphoinositide 3-kinase
C2-domain-containing phosphoinositide 3-kinase
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 3-phosphotransferase

Reaction

Comments:

This enzyme also phosphorylates PtdIns to PtdIns3P. Three mammalian isoforms have been found to date.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00710
Structural data: CSA , EC2PDB
Gene Ontology: GO:0035005
UniProtKB/Swiss-Prot:

References

  1. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D.
    Synthesis and function of 3-phosphorylated inositol lipids.
    Annu. Rev. Biochem. 70: 535-602 (2001). [PMID: 11395417]

[EC 2.7.1.154 created 2002]