EC 2 - Transferases
EC 2.7 - Transferring phosphorus-containing groups
EC 2.7.1 - Phosphotransferases with an alcohol group as acceptor
EC 2.7.1.147 - ADP-specific glucokinase
IntEnz view
ENZYME view
IntEnz Enzyme Nomenclature
EC 2.7.1.147
Names
Accepted name:
ADP-specific glucokinase
Other
name:
ADP-dependent glucokinase
Systematic name:
ADP:D-glucose 6-phosphotransferase
Reaction
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11460 [IUBMB]D-glucoseName origin: UniProt - CHECKED (C)Formula: C6H12O6
Charge: 0ChEBI compound status: CHECKED (C)ADPName origin: UniProt - CHECKED (C)Formula: C10H12N5O10P2
Charge: -3ChEBI compound status: CHECKED (C)<?>D-glucose 6-phosphateName origin: UniProt - CHECKED (C)Formula: C6H11O9P
Charge: -2ChEBI compound status: CHECKED (C)AMPName origin: UniProt - CHECKED (C)Formula: C10H12N5O7P
Charge: -2ChEBI compound status: CHECKED (C)
Cofactor
Comments:
Requires Mg2+. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
Links to other databases
Gene Ontology:
GO:0043843
References
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Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.J. Biol. Chem. 270: 30453-30457 (1995). [PMID: 8530474]
[EC 2.7.1.147 created 2001]