IntEnz

EC 2.7.1.147 - ADP-specific glucokinase

IntEnz Enzyme Nomenclature
EC 2.7.1.147

Names

Reaction

• 11463 [IUBMB]
  D-glucose

  D-glucose

  Name origin: UniProt - CHECKED (C)

  CHEBI:4167

  Formula: C6H12O6
  Charge: 0

  ChEBI compound status: CHECKED (C)

  

  +

  ADP

  ADP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456216

  Formula: C10H12N5O10P2
  Charge: -3

  ChEBI compound status: CHECKED (C)

  

  <=>

  D-glucose 6-phosphate

  D-glucose 6-phosphate

  Name origin: UniProt - CHECKED (C)

  CHEBI:61548

  Formula: C6H11O9P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  AMP

  AMP

  Name origin: UniProt - CHECKED (C)

  CHEBI:456215

  Formula: C10H12N5O7P
  Charge: -2

  ChEBI compound status: CHECKED (C)

  

  +

  H⁺

  H(+)

  Name origin: UniProt - CHECKED (C)

  CHEBI:15378

  Formula: H
  Charge: 1

  ChEBI compound status: CHECKED (C)

  

Cofactor

• Mg²⁺

Comments:

Requires Mg²⁺. The enzyme from Pyrococcus furiosus is highly specific for D-glucose; there is some activity with 2-deoxy-D-glucose, but no activity with D-fructose, D-mannose or D-galactose as the substrate. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.

Links to other databases

References

1. Kengen, S.W., Tuininga, J.E., de Bok, F.A., Stams, A.J. and de Vos, W.M.
   Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
   J. Biol. Chem. 270: 30453-30457 (1995). [PMID: 8530474]

[EC 2.7.1.147 created 2001]