EC 2.7.1.137 - Phosphatidylinositol 3-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.137

Names

Accepted name:
phosphatidylinositol 3-kinase
Other names:
1-phosphatidylinositol 3-kinase
Vps34p
type I phosphatidylinositol kinase
type III phosphoinositide 3-kinase
PtdIns-3-kinase
PI3-kinase
Systematic name:
ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase

Reaction

Comments:

One mammalian isoform is known.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00710
Structural data: CSA , EC2PDB
Gene Ontology: GO:0016303
CAS Registry Number: 115926-52-8
UniProtKB/Swiss-Prot: (20) [show] [UniProt]

References

  1. Whitman, M., Downes, C.P., Keeler, M., Keller, T. and Cantley, L.
    Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate.
    Nature 332: 644-646 (1988). [PMID: 2833705]
  2. Vanhaesebroeck, B., Leevers, S.J., Ahmadi, K., Timms, J., Katso, R., Driscoll, P.C., Woscholski, R., Parker, P.J. and Waterfield, M.D.
    Synthesis and function of 3-phosphorylated inositol lipids.
    Annu. Rev. Biochem. 70: 535-602 (2001). [PMID: 11395417]

[EC 2.7.1.137 created 1992, modified 2002]