EC 2.7.1.130 - Tetraacyldisaccharide 4'-kinase

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IntEnz Enzyme Nomenclature
EC 2.7.1.130

Names

Accepted name:
tetraacyldisaccharide 4'-kinase
Other name:
lipid-A 4'-kinase
Systematic name:
ATP:2,3,2',3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-β-D-glucosaminyl-(1→6)-α-D-glucosaminyl-phosphate 4'-O-phosphotransferase

Reaction

Comments:

Involved with EC 2.3.1.129 (acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0009029
CAS Registry Number: 107309-06-8
UniProtKB/Swiss-Prot: (376) [show] [UniProt]

References

  1. Ray, B.L. and Raetz C.R.H.
    The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A.
    J. Biol. Chem. 262: 1122-1128 (1987). [PMID: 3027079]

[EC 2.7.1.130 created 1990]