EC 2.7.1.127 - Inositol-trisphosphate 3-kinase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.7.1.127

Names

Accepted name:
inositol-trisphosphate 3-kinase
Other names:
IP3K
IP3 3-kinase
Inositol 1,4,5-trisphosphate 3-kinase
1D-myo-inositol-trisphosphate 3-kinase
Ins(1,4,5)P3 3-kinase
Systematic name:
ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase

Reaction

Cofactor

Comments:

Activated by Ca2+. Three isoforms have been shown to exist [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008440
CAS Registry Number: 106283-10-7
UniProtKB/Swiss-Prot:

References

  1. Hansen, C.A., Mah, S. and Williamson, J.R.
    Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.
    J. Biol. Chem. 261: 8100-8103 (1986). [PMID: 3487541]
  2. Irvine, R.F., Letcher, A.J., Heslop, J.P. and Berridge, M.J.
    The inositol tris/tetrakisphosphate pathway - demonstration of Ins(1,4,5)P3 3-kinase activity in animal tissues.
    Nature 320: 631-634 (1986). [PMID: 3010126]
  3. Irvine, R.F. and Schell, M.J.
    Back in the water - the return of the inositol phosphates.
    Nat. Rev. Mol. Cell. Biol. 2: 327-338 (2001). [PMID: 11331907]

[EC 2.7.1.127 created 1989, modified 2002]