EC 2.7.1.107 - Diacylglycerol kinase (ATP)

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IntEnz Enzyme Nomenclature
EC 2.7.1.107

Names

Accepted name:
diacylglycerol kinase (ATP)
Other names:
1,2-diacylglycerol kinase [ambiguous]
1,2-diacylglycerol kinase (phosphorylating) [ambiguous]
sn-1,2-diacylglycerol kinase [ambiguous]
ATP:diacylglycerol phosphotransferase
DG kinase [ambiguous]
DGK [ambiguous]
arachidonoyl-specific diacylglycerol kinase
diacylglycerol:ATP kinase
diglyceride kinase [ambiguous]
ATP:1,2-diacylglycerol 3-phosphotransferase
diacylglycerol kinase (ATP dependent)
Systematic name:
ATP:1,2-diacyl-sn-glycerol 3-phosphotransferase

Reaction

Comments:

Involved in synthesis of membrane phospholipids and the neutral lipid triacylglycerol. Activity is stimulated by certain phospholipids [4,7]. In plants and animals the product 1,2-diacyl-sn-glycerol 3-phosphate is an important second messenger. cf. EC 2.7.1.174, diacylglycerol kinase (CTP).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00820 , PROSITE:PDOC50146
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004143
CAS Registry Number: 60382-71-0
UniProtKB/Swiss-Prot: (81) [show] [UniProt]

References

  1. Daleo, G.R., Piras, M.M. and Piras, R.
    Diglyceride kinase activity of microtubules. Characterization and comparison with the protein kinase and ATPase activities associated with vinblastine-isolated tubulin of chick embryonic muscles.
    Eur. J. Biochem. 68: 339-346 (1976). [PMID: 185051]
  2. Hokin, L.E. and Hokin, M.R.
    Diglyceride kinase and other pathways for phosphatidic acid synthesis in the erythrocyte membrane.
    Biochim. Biophys. Acta 67: 470-484 (1963). [PMID: 13961253]
  3. Weissbach, H., Thomas, E. and Kaback, H.R.
    Studies on the metabolism of ATP by isolated bacterial membranes: formation and metabolism of membrane-bound phosphatidic acid.
    Arch. Biochem. Biophys. 147: 249-254 (1971). [PMID: 4940043]
  4. Walsh, J. P., Bell, R. M.
    sn-1,2-Diacylglycerol kinase of Escherichia coli. Structural and kinetic analysis of the lipid cofactor dependence.
    J. Biol. Chem. 261: 15062-15069 (1986). [PMID: 3021764]
  5. Russ, E., Kaiser, U., Sandermann, H.
    Lipid-dependent membrane enzymes. Purification to homogeneity and further characterization of diacylglycerol kinase from Escherichia coli.
    Eur. J. Biochem. 171: 335-342 (1988). [PMID: 2828054]
  6. Walsh, J. P., Bell, R. M.
    Diacylglycerol kinase from Escherichia coli.
    Meth. Enzymol. 209: 153-162 (1992). [PMID: 1323028]
  7. Wissing, J. B., Wagner, K. G.
    Diacylglycerol kinase from suspension cultured plant cells : characterization and subcellular localization.
    Plant Physiol. 98: 1148-1153 (1992). [PMID: 16668739]

[EC 2.7.1.107 created 1984, modified 2013]