EC 2.6.99.2 - Pyridoxine 5'-phosphate synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.6.99.2

Names

Accepted name:
pyridoxine 5'-phosphate synthase
Other names:
pyridoxine 5-phosphate phospho lyase
PNP synthase
PdxJ
Systematic name:
1-deoxy-D-xylulose-5-phosphate:3-amino-2-oxopropyl phosphate 3-amino-2-oxopropyltransferase (phosphate-hydrolysing; cyclizing)

Reaction

Comments:

In Escherichia coli, the coenzyme pyridoxal 5'-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5'-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5'-phosphate as substrate). 1-Deoxy-D-xylulose cannot replace 1-deoxy-D-xylulose 5-phosphate as a substrate [3].

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0033856
UniProtKB/Swiss-Prot: (259) [show] [UniProt]

References

  1. Garrido-Franco, M.
    Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond.
    Biochim. Biophys. Acta 1647: 92-97 (2003). [PMID: 12686115]
  2. Garrido-Franco, M., Laber, B., Huber, R. and Clausen, T.
    Enzyme-ligand complexes of pyridoxine 5'-phosphate synthase: implications for substrate binding and catalysis.
    J. Mol. Biol. 321: 601-612 (2002). [PMID: 12206776]
  3. Laber, B., Maurer, W., Scharf, S., Stepusin, K. and Schmidt, F.S.
    Vitamin B6 biosynthesis: formation of pyridoxine 5'-phosphate from 4-(phosphohydroxy)-L-threonine and 1-deoxy-D-xylulose-5-phosphate by PdxA and PdxJ protein.
    FEBS Lett. 449: 45-48 (1999). [PMID: 10225425]
  4. Franco, M.G., Laber, B., Huber, R. and Clausen, T.
    Structural basis for the function of pyridoxine 5'-phosphate synthase.
    Structure 9: 245-253 (2001). [PMID: 11286891]

[EC 2.6.99.2 created 2006]