EC 2.6.1.85 - Aminodeoxychorismate synthase

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IntEnz Enzyme Nomenclature
EC 2.6.1.85

Names

Accepted name:
aminodeoxychorismate synthase
Other names:
4-amino-4-deoxychorismate synthase
ADC synthase
PabB
chorismate:L-glutamine amido-ligase [incorrect]
Systematic name:
chorismate:L-glutamine aminotransferase

Reaction

Cofactor

Comments:

The enzyme is composed of two parts, PabA and PabB. In the absence of PabA and glutamine, PabB converts ammonia and chorismate into 4-amino-4-deoxychorismate (in the presence of Mg2+). PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00948
Structural data: CSA , EC2PDB
Gene Ontology: GO:0046820
CAS Registry Number: 132264-37-0
UniProtKB/Swiss-Prot: (18) [show] [UniProt]

References

  1. Ye, Q.Z., Liu, J. and Walsh, C.T.
    p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase.
    Proc. Natl. Acad. Sci. USA 87: 9391-9395 (1990). [PMID: 2251281]
  2. Viswanathan, V.K., Green, J.M. and Nichols, B.P.
    Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli.
    J. Bacteriol. 177: 5918-5923 (1995). [PMID: 7592344]

[EC 2.6.1.85 created 2003 as EC 6.3.5.8, transferred 2007 to EC 2.6.1.85]