EC 2.6.1.2 - Alanine transaminase

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IntEnz Enzyme Nomenclature
EC 2.6.1.2

Names

Accepted name:
alanine transaminase
Other names:
β-alanine aminotransferase
L-alanine aminotransferase
L-alanine transaminase
L-alanine—α-ketoglutarate aminotransferase
ALT
GPT
alanine aminotransferase
alanine—α-ketoglutarate aminotransferase
alanine—pyruvate aminotransferase
glutamic acid—pyruvic acid transaminase
glutamic—alanine transaminase
glutamic—pyruvic aminotransferase
glutamic—pyruvic transaminase
pyruvate transaminase
pyruvate—alanine aminotransferase
pyruvate—glutamate transaminase
Systematic name:
L-alanine:2-oxoglutarate aminotransferase

Reaction

Cofactor

Comments:

A pyridoxal-phosphate protein. 2-Aminobutanoate can act slowly instead of alanine.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , NIST 74 , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004021
CAS Registry Number: 9000-86-6
UniProtKB/Swiss-Prot: (25) [show] [UniProt]

References

  1. Dumitru, I.F., Iordachescu, D. and Niculescu, S.
    Chromatographic purification, crystallization and study of vegetable L-alanine: 2-oxoglutarate-aminotransferase properties.
    Experientia 26: 837-838 (1970). [PMID: 5452003]
  2. Dumitru, I.F., Iordachescu, D. and Niculescu, S.
    L-Alanine: 2-oxoglutarate-aminotransferase chromatographic purification and crystallization of the enzyme from seeds of Glycine hispida var
    Cheepeura. Rev. Roum. Biochim. 7: 31-44 (1970).
  3. Green, D.E., Leloir, L.F. and Nocito, W.
    Transaminases.
    J. Biol. Chem. 161: 559-582 (1945).
  4. Iordachescu, D., Dumitru, I.F. and Corniciuc, M.-T.
    Comparative biochemical studies concerning L-alanine: 2-oxoglutarate-aminotransferase from the liver and the bile of swines.
    Rev. Roum. Biochim. 20: 173-179 (1983).
  5. Wilson, D.G., King, K.W. and Burris, R.H.
    Transaminase reactions in plants.
    J. Biol. Chem. 208: 863-874 (1954).

[EC 2.6.1.2 created 1961]