EC 2.5.1.91 - all-trans-decaprenyl-diphosphate synthase

  IntEnz view ENZYME view

IntEnz Enzyme Nomenclature
EC 2.5.1.91

Names

Accepted name:
all-trans-decaprenyl-diphosphate synthase
Other names:
decaprenyl-diphosphate synthase
decaprenyl pyrophosphate synthetase
polyprenylpyrophosphate synthetase
terpenoidallyltransferase
terpenyl pyrophosphate synthetase
trans-prenyltransferase
Systematic name:
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 7 isopentenyl units)

Reaction

Comments:

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-decaprenyl diphosphate, the isoprenoid side chain of ubiquinone-10 and menaquinone-10. The enzyme adds seven isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
UniProtKB/Swiss-Prot:

References

  1. Saiki, R., Nagata, A., Kainou, T., Matsuda, H., Kawamukai, M.
    Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans.
    FEBS J. 272: 5606-5622 (2005). [PMID: 16262699]

[EC 2.5.1.91 created 2010]