EC 2.5.1.57 - N-acylneuraminate-9-phosphate synthase

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IntEnz Enzyme Nomenclature
EC 2.5.1.57

Names

Accepted name:
N-acylneuraminate-9-phosphate synthase
Other names:
N-acetylneuraminate 9-phosphate lyase
N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase
N-acetylneuraminate 9-phosphate synthetase
N-acylneuraminate-9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
sialic acid 9-phosphate synthetase
Systematic name:
phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase

Reaction

Comments:

Acts on N-glycoloyl and N-acetyl-derivatives.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , DIAGRAM , DIAGRAM , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Structural data: CSA , EC2PDB
Gene Ontology: GO:0047444
CAS Registry Number: 9031-58-7
UniProtKB/Swiss-Prot:

References

  1. Roseman, S., Jourdian, G.W., Watson, D. and Rood, R.
    Enzymatic synthesis of sialic acid 9-phosphates.
    Proc. Natl. Acad. Sci. USA 47: 958-961 (1961).
  2. Watson, D.R., Jourdian, G.W. and Roseman, S.
    The sialic acids. 8. Sialic acid 9-phosphate synthetase.
    J. Biol. Chem. 241: 5627-5636 (1966). [PMID: 5928202]
  3. Nakata, D., Close, B.E., Colley, K.J., Matsuda, T. and Kitajima, K.
    Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity.
    Biochem. Biophys. Res. Commun. 273: 642-648 (2000). [PMID: 10873658]

[EC 2.5.1.57 created 1972 as EC 4.1.3.20, transferred 2002 to EC 2.5.1.57]